[HTML][HTML] Identification of a ryanodine receptor in rat heart mitochondria
G Beutner, VK Sharma, DR Giovannucci, DI Yule…�- Journal of Biological�…, 2001 - ASBMB
Recent studies have shown that, in a wide variety of cells, mitochondria respond
dynamically to physiological changes in cytosolic Ca 2+ concentrations ([Ca 2+] c).
Mitochondrial Ca 2+ uptake occurs via a ruthenium red-sensitive calcium uniporter and a
rapid mode of Ca 2+ uptake. Surprisingly, the molecular identity of these Ca 2+ transport
proteins is still unknown. Using electron microscopy and Western blotting, we identified a
ryanodine receptor in the inner mitochondrial membrane with a molecular mass of�…
dynamically to physiological changes in cytosolic Ca 2+ concentrations ([Ca 2+] c).
Mitochondrial Ca 2+ uptake occurs via a ruthenium red-sensitive calcium uniporter and a
rapid mode of Ca 2+ uptake. Surprisingly, the molecular identity of these Ca 2+ transport
proteins is still unknown. Using electron microscopy and Western blotting, we identified a
ryanodine receptor in the inner mitochondrial membrane with a molecular mass of�…