Elevated platelet factor 4 and β-thromboglobulin plasma levels in depressed patients with ischemic heart disease
F Laghrissi-Thode, WR Wagner, BG Pollock…�- Biological�…, 1997 - Elsevier
Clinical depression has recently been recognized as an independent risk factor for cardiac
mortality in patients after myocardial infarction. The underlying mechanisms of this increased
mortality remain unclear. This study investigated the hypothesis that patients suffering from
ischemic heart disease (IHD) and depression concurrently may have abnormal platelet
activation resulting in an increased risk of thrombosis. Platelet factor 4 (PF4) and β-
thromboglobulin (β-TG) were measured in young healthy control subjects, in nondepressed�…
mortality in patients after myocardial infarction. The underlying mechanisms of this increased
mortality remain unclear. This study investigated the hypothesis that patients suffering from
ischemic heart disease (IHD) and depression concurrently may have abnormal platelet
activation resulting in an increased risk of thrombosis. Platelet factor 4 (PF4) and β-
thromboglobulin (β-TG) were measured in young healthy control subjects, in nondepressed�…