Evidence for a local change in the progesterone/estrogen ratio in human parturition at term

R Romero, B Scoccia, M Mazor, YK Wu…�- American journal of�…, 1988 - Elsevier
The purpose of this study was to determine if a local change in the concentrations of
estrogen and progesterone occurs in the amniotic fluid during human parturition at term.
Amniotic fluid was retrieved from 20 women in active labor and from 20 women not in labor.
Patients were matched for maternal age and gestational age. Estradiol, estriol,
progesterone, and dehydroepiandrosterone sulfate were measured in amniotic fluid by
radioimmunoassay. For women in active labor, the median concentrations (range) of these�…