[HTML][HTML] Strategic positioning and biased activity of the mitochondrial calcium uniporter in cardiac muscle
S De La Fuente, C Fernandez-Sanz, C Vail…�- Journal of Biological�…, 2016 - ASBMB
Control of myocardial energetics by Ca 2+ signal propagation to the mitochondrial matrix
includes local Ca 2+ delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2)
to the inner mitochondrial membrane (IMM) Ca 2+ uniporter (mtCU). mtCU activity in cardiac
mitochondria is relatively low, whereas the IMM surface is large, due to extensive cristae
folding. Hence, stochastically distributed mtCU may not suffice to support local Ca 2+
transfer. We hypothesized that mtCU concentrated at mitochondria-SR associations would�…
includes local Ca 2+ delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2)
to the inner mitochondrial membrane (IMM) Ca 2+ uniporter (mtCU). mtCU activity in cardiac
mitochondria is relatively low, whereas the IMM surface is large, due to extensive cristae
folding. Hence, stochastically distributed mtCU may not suffice to support local Ca 2+
transfer. We hypothesized that mtCU concentrated at mitochondria-SR associations would�…