NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
AR Mridha, A Wree, AAB Robertson, MM Yeh…�- Journal of�…, 2017 - Elsevier
Background & Aims NOD-like receptor protein 3 (NLRP3) inflammasome activation occurs in
Non-alcoholic fatty liver disease (NAFLD). We used the first small molecule NLRP3 inhibitor,
MCC950, to test whether inflammasome blockade alters inflammatory recruitment and liver
fibrosis in two murine models of steatohepatitis. Methods We fed foz/foz and wild-type mice
an atherogenic diet for 16 weeks, gavaged MCC950 or vehicle until 24 weeks, then
determined NAFLD phenotype. In mice fed an methionine/choline deficient (MCD) diet, we�…
Non-alcoholic fatty liver disease (NAFLD). We used the first small molecule NLRP3 inhibitor,
MCC950, to test whether inflammasome blockade alters inflammatory recruitment and liver
fibrosis in two murine models of steatohepatitis. Methods We fed foz/foz and wild-type mice
an atherogenic diet for 16 weeks, gavaged MCC950 or vehicle until 24 weeks, then
determined NAFLD phenotype. In mice fed an methionine/choline deficient (MCD) diet, we�…