Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
A Leroux, G Ferrere, V Godie, F Cailleux…�- Journal of�…, 2012 - Elsevier
BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is characterized by steatosis
associated with liver inflammation. Steatosis causes recruitment of lymphocytes into the liver
and this is worsened by lipopolysaccharides (LPS). As macrophages may be involved in the
lymphocyte homing, we studied the role of lipids in determining the phenotype of Kupffer
cells (KCs) at the stage of steatosis. METHODS: Steatosis was induced in mice by a high fat
diet. The turnover and the recruitment of KCs were analyzed in vivo by flow cytometry. KCs�…
associated with liver inflammation. Steatosis causes recruitment of lymphocytes into the liver
and this is worsened by lipopolysaccharides (LPS). As macrophages may be involved in the
lymphocyte homing, we studied the role of lipids in determining the phenotype of Kupffer
cells (KCs) at the stage of steatosis. METHODS: Steatosis was induced in mice by a high fat
diet. The turnover and the recruitment of KCs were analyzed in vivo by flow cytometry. KCs�…