Cognitive impairment following high fat diet consumption is associated with brain inflammation
PJ Pistell, CD Morrison, S Gupta, AG Knight…�- Journal of�…, 2010 - Elsevier
C57Bl/6 mice were administered a high fat, Western diet (WD, 41% fat) or a very high fat lard
diet (HFL, 60% fat), and evaluated for cognitive ability using the Stone T-maze and for
biochemical markers of brain inflammation. WD consumption resulted in significantly
increased body weight and astrocyte reactivity, but not impaired cognition, microglial
reactivity, or heightened cytokine levels. HFL increased body weight, and impaired
cognition, increased brain inflammation, and decreased BDNF. Collectively, these data�…
diet (HFL, 60% fat), and evaluated for cognitive ability using the Stone T-maze and for
biochemical markers of brain inflammation. WD consumption resulted in significantly
increased body weight and astrocyte reactivity, but not impaired cognition, microglial
reactivity, or heightened cytokine levels. HFL increased body weight, and impaired
cognition, increased brain inflammation, and decreased BDNF. Collectively, these data�…