Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese
J Aron-Wisnewsky, C Minville, J Tordjman, P L�vy…�- Journal of�…, 2012 - Elsevier
BACKGROUND & AIMS: Morbid obesity is frequently associated with low grade systemic
inflammation, increased macrophage accumulation in adipose tissue (AT), obstructive sleep
apnea (OSA), and nonalcoholic fatty liver disease (NAFLD). It has been suggested that
chronic intermittent hypoxia (CIH) resulting from OSA could be an independent factor for
early stage of NAFLD in addition to other well-recognized factors (dyslipidemia or insulin
resistance). Moreover, macrophage accumulation in AT is associated with local hypoxia in�…
inflammation, increased macrophage accumulation in adipose tissue (AT), obstructive sleep
apnea (OSA), and nonalcoholic fatty liver disease (NAFLD). It has been suggested that
chronic intermittent hypoxia (CIH) resulting from OSA could be an independent factor for
early stage of NAFLD in addition to other well-recognized factors (dyslipidemia or insulin
resistance). Moreover, macrophage accumulation in AT is associated with local hypoxia in�…