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The brain is a network of interleaved neural circuits. In modern connectomics, brain
connectivity is typically encoded as a network of nodes and edges, abstracting away
the rich biological detail of local neuronal populations. Yet biological annotations for�…

Modern brainwide transcriptional atlases provide unprecedented opportunities for
investigating the molecular correlates of brain organization, as quantified using
noninvasive neuroimaging. However, integrating neuroimaging data with�…

The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder
(ASD) are not well understood. Using a large neuroimaging dataset, we identified
three latent dimensions of functional brain network connectivity that predicted�…

Genes associated with risk for brain disease exhibit characteristic expression
patterns that reflect both anatomical and cell type relationships. Brain-wide
transcriptomic patterns of disease risk genes provide a molecular-based signature�…

Functional changes of white matter are largely unexplored in patients with psychiatric
disorders. This study examined white matter dysfunctions common in four major
psychiatric disorders (including schizophrenia, major depressive disorder, bipolar�…

Mental rotation, one of the cores of spatial cognitive abilities, is closely associated
with spatial processing and general intelligence. Although the brain underpinnings of
mental rotation have been reported, the cellular and molecular mechanisms remain�…

Neuroscience research has entered a phase of key discoveries in the realm of
neurogenomics owing to strong financial and intellectual support for resource
building and tool development. The previous challenge of tissue heterogeneity has�…

The human brain is organized as segregation and integration units and follows
complex developmental trajectories throughout life. The cortical manifold provides a
new means of studying the brain's organization in a multidimensional connectivity�…

Systematic spatial variation in micro-architecture is observed across the cortex.
These micro-architectural gradients are reflected in neural activity, which can be
captured by neurophysiological time-series. How spontaneous neurophysiological�…

Aneuploidy syndromes impact multiple organ systems but understanding of tissue-
specific aneuploidy effects remains limited—especially for the comparison between
peripheral tissues and relatively inaccessible tissues like brain. Here, we address�…