Precise timing in hormone release from the hypothalamus, the pituitary and ovary is critical
for fertility. Hormonal release patterns of the reproductive axis are regulated by a feedback�…

A fundamental principle in reproductive neuroendocrinology is sex steroid feedback: steroid
hormones secreted by the gonads circulate back to the brain to regulate the neural circuits�…

Signals from the central circadian pacemaker, the suprachiasmatic nucleus (SCN), must be
decoded to generate daily rhythms in hormone release. Here, we hypothesized that the SCN�…

Simple Summary In mammals, circadian rhythms in nearly all behaviors and physiological
processes are controlled by the suprachiasmatic nucleus, a collection of neurons in the�…

Brain and muscle aryl-hydrocarbon receptor nuclear translocator like protein1 (BMAL1), a
core component of circadian oscillation, is involved in many physiological activities�…

Transcription factors (TFs) control cell identity and function. How their activity is altered
during healthy aging is critical for an improved understanding of aging and disease risk, yet�…

Fertility in mammals is ultimately controlled by a small population of neurons–the
gonadotropin-releasing hormone (GnRH) neurons–located in the ventral forebrain. GnRH�…

Obesity is associated with hypogonadism in males, characterized by low testosterone and
sperm number. Previous studies determined that these stem from dysregulation of�…

For billions of years before electric light was invented, life on Earth evolved under the pattern
of light during the day and darkness during the night. Through evolution, nearly all�…

The circadian system is an inbuilt timekeeping mechanism that tracks the 24-h day through
the generation of circadian rhythms. Circadian rhythms enable animals to forecast and�…