Abstract Apolipoprotein C-II (apoC-II) is a small exchangeable apolipoprotein found on
triglyceride-rich lipoproteins (TRL), such as chylomicrons (CM) and very low-density�…

Lipid uptake and metabolism are central to the function of organs such as heart, skeletal
muscle, and adipose tissue. Although most heart energy derives from fatty acids (FAs)�…

Genome wide association, epidemiological, and clinical studies have established high
lipoprotein (a)[Lp (a)] as a causal risk factor for atherosclerotic cardiovascular disease�…

Background In 2013, our laboratory designed a targeted sequencing panel,“LipidSeq”, to
study the genetic determinants of dyslipidemia and metabolic disorders. Over the last 6�…

Triacylglycerol (TG) metabolism is tightly regulated to maintain a pool of TG within circulating
lipoproteins that can be hydrolyzed in a tissue‐specific manner by lipoprotein lipase (LPL) to�…

Abstract Aims Apolipoprotein C-II (ApoC-II) is thought to activate lipoprotein lipase (LPL) and
is therefore a possible target for treating hypertriglyceridemia. Its relationship with�…

After feeding, adipose tissue lipoprotein lipase (LPL) activity should be maximized, therefore
the potent LPL-inhibitory activity of angiopoietin-like protein 4 (ANGPTL4) must be blocked�…

Abstract Familial Chylomicronemia Syndrome (FCS) is a rare autosomal recessive lipid
disorder characterized by severe hypertriglyceridemia and recurrent pancreatitis. Because�…

Human studies support a strong association between hypertriglyceridemia and
atherosclerotic cardiovascular disease (CVD). However, whether a causal relationship�…

Background Familial chylomicronemia syndrome (FCS) is a rare metabolic disorder caused
by mutations in lipoprotein lipase (LPL) or genes required for LPL functionality and is�…