The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction�…

The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and�…

The mechanism by which arcuate nucleus kisspeptin (ARN KISS) neurons co-expressing
glutamate, neurokinin B, and dynorphin intermittently synchronize their activity to generate�…

The mechanisms underlying the homeostatic estrogen negative feedback pathway central to
mammalian fertility have remained unresolved. Direct measurement of gonadotropin�…

Increasing evidence accumulated during the past two decades has demonstrated that the
then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin�…

A fundamental principle in reproductive neuroendocrinology is sex steroid feedback: steroid
hormones secreted by the gonads circulate back to the brain to regulate the neural circuits�…

The gonadal steroids estradiol and progesterone exert critical suppressive and stimulatory
actions upon the brain to control gonadotropin-releasing hormone (GnRH) release that�…

Estrogen produced by ovarian follicles plays a key role in the central mechanisms
controlling reproduction via regulation of gonadotropin-releasing hormone (GnRH) release�…

Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine disorder associated with
hyperandrogenism and anovulation. Although a spectrum disorder, many women with�…

A subpopulation of kisspeptin neurons located in the arcuate nucleus (ARN) operate as the
GnRH pulse generator. The activity of this population of neurons can be monitored in real�…