Pseudarthrosis continues to affect a nontrivial proportion of spine fusion patients. Given its
ties to poorer patient outcomes and high reoperation rates, there remains great interest in
interventions aimed at reducing the rates of nonunion. Recently, silicate-substituted calcium
phosphate (SiCaP) bone grafts have been suggested to improve fusion rates, yet there
exists no systematic review of the body of evidence for SiCaP grafts. Here, we present the
first such review along with a meta-analysis of the effect of SiCaP bone grafts on fusion�…

Pseudarthrosis following spinal fusion is correlated with poorer patient outcomes and
consequently is an area of continued interest within spinal research. Recently, bioactive
glasses have been proposed as a means of augmenting fusion rates. Here, we present the
first systematic review and meta-analysis of the existing preclinical and clinical literature on
the effect of bioactive glasses on spinal fusion. Using the MEDLINE, Embase, and Web of
Science databases, we queried all publications in the English-language literature examining�…