TM or not TM: transmembrane protein prediction with low false positive rate using DAS-TMfilter
Bioinformatics, 2004•academic.oup.com
Web-based servers implementing the DAS-TMfilter algorithm have been launched at three
mirror sites and their usage is described. The underlying computer program is an upgraded
and modified version of the DAS-prediction method. The new server is designed to make
distinction between protein sequences with and without transmembrane (TM) helices at a
reasonably low rate of false positive prediction (∼ 1 among 100 unrelated queries) while the
high efficiency of the original algorithm locating TM segments in queries is preserved�…
mirror sites and their usage is described. The underlying computer program is an upgraded
and modified version of the DAS-prediction method. The new server is designed to make
distinction between protein sequences with and without transmembrane (TM) helices at a
reasonably low rate of false positive prediction (∼ 1 among 100 unrelated queries) while the
high efficiency of the original algorithm locating TM segments in queries is preserved�…
Abstract
Summary: Web-based servers implementing the DAS-TMfilter algorithm have been launched at three mirror sites and their usage is described. The underlying computer program is an upgraded and modified version of the DAS-prediction method. The new server is designed to make distinction between protein sequences with and without transmembrane (TM) helices at a reasonably low rate of false positive prediction (∼1 among 100 unrelated queries) while the high efficiency of the original algorithm locating TM segments in queries is preserved (sensitivity of ∼95% among documented proteins with helical TM regions).
Availability: The server operates at three mirror sites: http://mendel.imp.univie.ac.at/sat/DAS/DAS.html, http://wooster.bip.bham.ac.uk/DAS.html and http://www.enzim.hu/DAS/DAS.html. The program is available on request.
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