Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications
BACKGROUND: Converging lines of evidence implicate the neurotrophin brain-derived
neurotrophic factor (BDNF) in the pathophysiology of major depression. Recent studies have
begun to explore the relationship between serum BDNF and depression. METHODS: We
conducted meta-analyses of 11 studies examining differences in serum BDNF content
between depressed and nondepressed subjects (N= 748), and eight studies comparing pre-
and post-antidepressant treatment serum BDNF content (N= 220). RESULTS: The meta�…
neurotrophic factor (BDNF) in the pathophysiology of major depression. Recent studies have
begun to explore the relationship between serum BDNF and depression. METHODS: We
conducted meta-analyses of 11 studies examining differences in serum BDNF content
between depressed and nondepressed subjects (N= 748), and eight studies comparing pre-
and post-antidepressant treatment serum BDNF content (N= 220). RESULTS: The meta�…
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