Aim: To quantify the lifetime health and economic consequences of preventing and treating
obesity with lifestyle intervention in Switzerland. Methods: A Markov model was developed
comparing lifestyle intervention and standard care in overweight and obese people.
Changes in weight and cardiovascular risk factors over time were modeled from reduction in
body mass index, systolic blood pressure, total cholesterol and high density lipoprotein in
three-year active treatment period. A probabilistic sensitivity analysis was performed. Three�…

Objective: To assess the mid-to long-term effectiveness of lifestyle interventions in the
prevention and treatment of obesity. Methods: A systematic literature review with meta-
analysis was performed. Electronic databases, reference lists, books and reports covering
topic of obesity were searched. The included studies were randomized clinical trials of
lifestyle interventions in overweight and obese subjects that had a minimum observation
period of one year. Outcomes evaluated were measurements of body weight, body mass�…