Prediction of spontaneous preterm delivery in women with preterm labor: analysis of multiple proteins in amniotic and cervical fluids

RM Holst, H Hagberg, UB Wennerholm…�- Obstetrics &�…, 2009 - journals.lww.com
OBJECTIVE: To analyze whether specific proteins in amniotic and cervical fluids, alone or in
combination with risk factors, can identify women in preterm labor with intact membranes
who will deliver spontaneously within 7 days of sampling. METHODS: In a cohort of 89
women in preterm labor, amniotic and cervical fluids were collected between 22 and 33
weeks of gestation. Twenty-seven proteins were analyzed simultaneously using multiplex
technology. Individual levels of each protein were compared and calculations performed to�…

146: Prediction of spontaneous preterm delivery in women with preterm labor: analysis of multiple proteins in maternal serum

P Tsiartas, RM Holst, UB Wennerholm…�- American Journal of�…, 2012 - ajog.org
Objective To analyze whether specific proteins in maternal serum and the cervical length,
alone or in combination, can identify the likelihood that women in preterm labor with intact
membranes will deliver spontaneously within 7 days of sampling. Study Design We used in
our study two independent cohorts of women, an exploratory cohort from 1995-2005 and a
confirmatory cohort from 2008-2010 admitted to the Sahlgrenska University Hospital,
Gothenburg, Sweden in preterm labor. In the exploratory cohort of 142 women in preterm�…
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