Diurnal variation of plasma brain‐derived neurotrophic factor (BDNF) in humans: an analysis of sex differences
A Piccinni, D Marazziti, A Del Debbio…�- Chronobiology�…, 2008 - Taylor & Francis
Scant information is available on the diurnal variation of peripheral neurotrophic factors,
including brain‐derived neurotrophic factor (BDNF), in human beings. We explored plasma
and serum BDNF levels at three different clock times in a study of 28 healthy subjects of both
sexes. Statistically significant diurnal variation in plasma BDNF level was detected in men,
with the peak at 08: 00 h and nadir at 22: 00 h. At this time, the plasma BDNF concentration
of men was significantly lower than that of women (p=. 02). However, no diurnal variation�…
including brain‐derived neurotrophic factor (BDNF), in human beings. We explored plasma
and serum BDNF levels at three different clock times in a study of 28 healthy subjects of both
sexes. Statistically significant diurnal variation in plasma BDNF level was detected in men,
with the peak at 08: 00 h and nadir at 22: 00 h. At this time, the plasma BDNF concentration
of men was significantly lower than that of women (p=. 02). However, no diurnal variation�…
Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments
A Piccinni, D Marazziti, M Catena, L Domenici…�- Journal of affective�…, 2008 - Elsevier
BACKGROUND: Brain-derived neurotrophic factor (BDNF) has been hypothesized to be
involved in the neurobiology of major depression. The aim of this study was to assess the
possible relationships between depressive symptoms and serum and/or plasma BDNF
levels during 1 year of antidepressant treatment. METHODS: Plasma and serum BDNF
levels were assayed in 15 drug-free depressed patients and in 15 healthy control subjects at
baseline and the 1st, 3rd, 6th and 12th month of antidepressant treatment. RESULTS: At�…
involved in the neurobiology of major depression. The aim of this study was to assess the
possible relationships between depressive symptoms and serum and/or plasma BDNF
levels during 1 year of antidepressant treatment. METHODS: Plasma and serum BDNF
levels were assayed in 15 drug-free depressed patients and in 15 healthy control subjects at
baseline and the 1st, 3rd, 6th and 12th month of antidepressant treatment. RESULTS: At�…
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