Next-generation sequencing reveals recurrent somatic mutations in small cell neuroendocrine carcinoma of the uterine cervix
D Xing, G Zheng, JK Schoolmeester, Z Li…�- The American journal�…, 2018 - journals.lww.com
Small cell neuroendocrine carcinoma (SCNEC) of the uterine cervix is a rare but extremely
aggressive tumor. While high-risk human papillomavirus (HPV) is involved at an early stage
of oncogenesis in many tumors, additional driving events have been postulated to facilitate
the progression of SCNECs. Identification of oncogenic drivers could guide targeted therapy
of this neoplasm. Clinicopathologic features of 10 cervical SCNECs are reported. Analyses
included immunohistochemical evaluation of p16, p53, synaptophysin, and chromogranin�…
aggressive tumor. While high-risk human papillomavirus (HPV) is involved at an early stage
of oncogenesis in many tumors, additional driving events have been postulated to facilitate
the progression of SCNECs. Identification of oncogenic drivers could guide targeted therapy
of this neoplasm. Clinicopathologic features of 10 cervical SCNECs are reported. Analyses
included immunohistochemical evaluation of p16, p53, synaptophysin, and chromogranin�…
Showing the best result for this search. See all results