Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs
F Karege, G Vaudan, M Schwald, N Perroud…�- Molecular Brain�…, 2005 - Elsevier
Suicide is a major public health problem but the neurobiological factors of risk are poorly
understood. Recent studies have mentioned changes in the serotoninergic system and in
neuronal plasticity, as well. The present investigation was undertaken to examine whether
there is an abnormality in brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-
3) proteins in suicide victims. The effect of diagnosis and drug treatments on the
neurotrophins was also assessed. Thirty suicide victims (11 F/19 M) and twenty-four (10 F/14�…
understood. Recent studies have mentioned changes in the serotoninergic system and in
neuronal plasticity, as well. The present investigation was undertaken to examine whether
there is an abnormality in brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-
3) proteins in suicide victims. The effect of diagnosis and drug treatments on the
neurotrophins was also assessed. Thirty suicide victims (11 F/19 M) and twenty-four (10 F/14�…
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