Although the etiology of autism remains largely unknown, cytogenetic and genetic studies
have implicated maternal copy number gains of 15q11–q13 in 1–3% of autism cases. In
order to understand how maternal 15q duplication leads to dysregulation of gene
expression and altered chromatin interactions, we used microcell-mediated chromosome
transfer to generate a novel maternal 15q duplication model in a human neuronal cell line.
Our 15q duplication neuronal model revealed that by quantitative RT–PCR, transcript levels�…

Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model
of human 15q-duplication syndrome | CiNii Research … CiNii Books … 細胞科学研究財団
助成研究報告集 = Bulletin of the Cell Science Research Foundation 22 11-24, 2011 …