[HTML][HTML] Evidence that oestrogen receptor-α plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver
G Bryzgalova, H Gao, B Ahr�n, JR Zierath, D Galuska…�- Diabetologia, 2006 - Springer
Aims/hypothesis We used oestrogen receptor-α (ERα) knockout (ERKO) and receptor-β
(ERβ) knockout (BERKO) mice to investigate the mechanism (s) behind the effects of
oestrogens on glucose homeostasis. Methods Endogenous glucose production (EGP) was
measured in ERKO mice using a euglycaemic–hyperinsulinaemic clamp. Insulin secretion
was determined from isolated islets. In isolated muscles, glucose uptake was assayed by
using radiolabelled isotopes. Genome-wide expression profiles were analysed by high�…
(ERβ) knockout (BERKO) mice to investigate the mechanism (s) behind the effects of
oestrogens on glucose homeostasis. Methods Endogenous glucose production (EGP) was
measured in ERKO mice using a euglycaemic–hyperinsulinaemic clamp. Insulin secretion
was determined from isolated islets. In isolated muscles, glucose uptake was assayed by
using radiolabelled isotopes. Genome-wide expression profiles were analysed by high�…
…�decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer�…
H Gao, G Bryzgalova, E Hedman, A Khan…�- Molecular�…, 2006 - academic.oup.com
In this study, we used ob/ob mice as a model to investigate the effects of long-term estradiol
administration on insulin sensitivity and to explore the mechanisms that underlie the
antidiabetic effects of estrogen on mouse liver. Female ob/ob mice were randomly divided
into two groups and given estradiol (100 μg/kg� d) or vehicle alone for 4 wk. Estrogen
administration improved glucose tolerance and insulin response to glucose in ob/ob mice.
Moreover, insulin resistance and liver triglyceride levels were decreased in response to�…
administration on insulin sensitivity and to explore the mechanisms that underlie the
antidiabetic effects of estrogen on mouse liver. Female ob/ob mice were randomly divided
into two groups and given estradiol (100 μg/kg� d) or vehicle alone for 4 wk. Estrogen
administration improved glucose tolerance and insulin response to glucose in ob/ob mice.
Moreover, insulin resistance and liver triglyceride levels were decreased in response to�…
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