Monocyte chemotactic protein-2 and-3 in amniotic fluid: relationship to microbial invasion of the amniotic cavity, intra-amniotic inflammation and preterm delivery
B Jacobsson, RM Holst, B Andersson…�- Acta obstetricia et�…, 2005 - Taylor & Francis
Objective. To evaluate the presence of monocyte chemotactic protein (MCP)-2 and MCP-3 in
cervical and amniotic fluid in women in preterm labor. Study design. Cervical and amniotic
fluid was sampled from women with singleton pregnancies (≤ 34 weeks) in preterm labor
(n= 58). Results. Monocyte chemotactic protein-2 (range: 80-583 pg/ml) and MCP-3 (range:
36-649 pg/ml) were detectable in 7/58 women in preterm labor. Monocyte chemotactic
protein-3 was found significantly more often in amniotic fluid of women delivered within 7�…
cervical and amniotic fluid in women in preterm labor. Study design. Cervical and amniotic
fluid was sampled from women with singleton pregnancies (≤ 34 weeks) in preterm labor
(n= 58). Results. Monocyte chemotactic protein-2 (range: 80-583 pg/ml) and MCP-3 (range:
36-649 pg/ml) were detectable in 7/58 women in preterm labor. Monocyte chemotactic
protein-3 was found significantly more often in amniotic fluid of women delivered within 7�…
…�interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation�…
RM Holst, I Mattsby-Baltzer…�- Acta obstetricia et�…, 2005 - Taylor & Francis
Background. Intrauterine infection and inflammation in women with preterm labor are related
to adverse perinatal outcome. Due to its subclinical nature, a correct diagnosis depends on
retrieval of amniotic fluid. Amniocentesis is, however, not performed as a clinical routine
because of its invasiveness. Hypothetically, cytokines in the cervical fluid may represent an
alternative diagnostic approach. The aim was to examine cervical interleukin (IL)-6 and IL-8
in relation to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and�…
to adverse perinatal outcome. Due to its subclinical nature, a correct diagnosis depends on
retrieval of amniotic fluid. Amniocentesis is, however, not performed as a clinical routine
because of its invasiveness. Hypothetically, cytokines in the cervical fluid may represent an
alternative diagnostic approach. The aim was to examine cervical interleukin (IL)-6 and IL-8
in relation to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and�…
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