Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor alpha (ERα): a potential role for estrogen receptor beta (ERβ)

A Naaz, M Zakroczymski, P Heine…�- Hormone and�…, 2002 - thieme-connect.com
adipose regulation, because estrogen receptor alpha knockout (αERKO) mice show over a
100 % increase … of αERKO mice results in decreased adipose tissue and improved insulin …

The role of estrogen and estrogen receptor-α in male adipose tissue

PS Cooke, PA Heine, JA Taylor, DB Lubahn�- Molecular and cellular�…, 2001 - Elsevier
… This increase in WAT in αERKO males (Heine et al., 2000), which is the focus of the
present review, was unexpected based on prevailing concepts of the role of ER in the …

[HTML][HTML] Importance of estrogen receptors in adipose tissue function

M Bl�her�- Molecular metabolism, 2013 - ncbi.nlm.nih.gov
… experimental evidence that AT and adipocyte estrogen receptor alpha (ERα) play an …
Heine et al. further demonstrated that increased fat mass in male and female ERα knockout mice

[HTML][HTML] The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis

KE Davis, MD Neinast, K Sun, WM Skiles, JD Bills…�- Molecular�…, 2013 - Elsevier
… , estrogen receptor alpha (ERα) and estrogen receptor beta (… males and females have
increased adipose tissue that has … Nuclei were pelleted at 2000�g, and washed twice with nuclei …

Loss of estrogen receptor α signaling leads to insulin resistance and obesity in young and adult female mice

C Manrique, G Lastra, J Habibi, I Mugerfeld…�- Cardiorenal�…, 2012 - karger.com
… results in obesity at the expense of white adipose tissue … significantly higher in female ERαKO
mice relative to female ERαWt in … Muraki K, Okuya S, Tanizawa Y: Estrogen receptor alpha

Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome

AL Hevener, DJ Clegg, F Mauvais-Jarvis�- Molecular and cellular�…, 2015 - Elsevier
… in body fat distribution as men have less total body fat but increased intra-abdominal
adipose tissue compared with women who have more total fat but a higher proportion of gluteal/…

Demonstration of estrogen receptor subtypes α and β in human adipose tissue: influences of adipose cell differentiation and fat depot localization

SB Pedersen, JM Bruun, F Hube, K Kristensen…�- Molecular and cellular�…, 2001 - Elsevier
tissue (five-fold lower in women, P<0.005 and three-fold lower in men, P<… higher in gluteal
adipose tissue compared to subcutaneous abdominal … Estrogen receptor alpha and beta …

[HTML][HTML] Estrogen receptor beta (ERβ) regulation of lipid Homeostasis—Does sex matter?

C Savva, M Korach-Andr��- Metabolites, 2020 - mdpi.com
… Recent studies using female and male animal models have highlighted the key role of …
adipose tissue (WAT) between genders. Female and male mice lacking ERβ (ERβKO) increased

[HTML][HTML] Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action

M Matic, G Bryzgalova, H Gao, P Antonson, P Humire…�- PloS one, 2013 - journals.plos.org
… total estrogen receptor alpha (ERα) knockout (KO) mice exhibit … women has been shown
to lower visceral adipose tissue, … observed increased levels of lipid droplets in female mouse

[HTML][HTML] Metabolic actions of estrogen receptor beta (ERβ) are mediated by a negative cross-talk with PPARγ

A Foryst-Ludwig, M Clemenz, S Hohmann…�- PLoS�…, 2008 - journals.plos.org
… its heterodimerization with retinoid x receptor alpha (RXRα), and … is the result of increased
adipose tissue mass, we performed … and transfected using lipofectamine 2000 and OptiMEM (…