OBJECTIVE: To assess the risk estimates for respiratory syncytial virus (RSV) hospitalization
in children with Down syndrome (DS) and the clinical features and severity of RSV lower
respiratory tract infection (LRTI) in hospitalized children. STUDY DESIGN: Statewide
hospitalization data for children with DS for 1995 through 2006 from the Colorado Health
and Hospital Association database were combined with birth data from the Colorado
Department of Public Health and Environment to obtain population-based estimates of RSV�…

Statewide respiratory syncytial virus (RSV) lower respiratory tract infection hospitalization
data of Colorado children with congenital malformations was used to estimate the
population-based risk and severity of disease of RSV hospitalizations. Spina bifida without
anencephaly, cleft palate, lung agenesis or dysgenesis, and biliary atresia were associated
with a higher risk of being hospitalized with RSV lower respiratory tract infection and an
increased severity of disease when hospitalized.