High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis
DP Relling, LB Esberg, CX Fang…�- Journal of�…, 2006 - journals.lww.com
Background Obesity is associated with dyslipidemia, which leads to elevated triglyceride
and ceramide levels, apoptosis and compromised cardiac function. Methods To determine
the role of high-fat diet-induced obesity on cardiomyocyte function, weanling male Sprague–
Dawley rats were fed diets incorporating 10% of kcal or 45% of kcal from fat. Mechanical
function of ventricular myocytes was evaluated including peak shortening (PS), time-to-PS
(TPS), time-to-90% relengthening (TR 90) and maximal velocity of shortening and�…
and ceramide levels, apoptosis and compromised cardiac function. Methods To determine
the role of high-fat diet-induced obesity on cardiomyocyte function, weanling male Sprague–
Dawley rats were fed diets incorporating 10% of kcal or 45% of kcal from fat. Mechanical
function of ventricular myocytes was evaluated including peak shortening (PS), time-to-PS
(TPS), time-to-90% relengthening (TR 90) and maximal velocity of shortening and�…
[CITATION][C] High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of Iipotoxicity and�…
J Murphya, EC Carlsonb, JT Saari, J Rena'd�- apoptosis, 2006
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