… We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest
human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 …

… lung cancers, but their precise relationship has remained unclear. Here we perform a
comprehensive genomic (n … pulmonary carcinoids (PCa) and small cell lung cancer (SCLC) 12,13 …

… morbidity among all cancers (1). Overall, approximately 15% of lung cancer cases are
diagnosed as small cell lung cancer (SCLC) (1,2). Combined small cell lung cancer (CSCLC), a …

… , is a target for immune checkpoint blockade; however, little is known about genomic CD274
alterations. A subset of small-cell lung cancer (SCLC) exhibits increased copy number of …

… Small cell lung cancer (SCLC) is accounting for 15% of all lung cancer cases and belongs
… This tumor entity additionally includes large-cell neuroendocrine carcinomas (LCNEC) and …

… In summary, this whole genome sequencing analysis provides a comprehensive understanding
of the genomic nature of SCLC tumors endorsing universal bi-allelic loss of TP53 and …

… Comprehensive genomic profiling using NGS identified clinically-actionable alterations in
SCLC patients who progressed on initial therapy. Recommended PD-1 therapy generated …

… a comprehensive genomic study of SCLC PDX models, which for the first time demonstrates
that the somatic mutational landscapes of the models closely match synchronous tumor …

… 4), a finding that supports the use of CTC-derived genetic profiles as clinically relevant …
We extended our analysis to genome-wide CNA profiles of individual CTCs and identified …

… The evolutionary processes that underlie the marked sensitivity of small cell lung cancer (SCLC)
to chemotherapy and rapid relapse are unknown 1,2,3 . Here we determined tumour …