Antibodies against fetal brain in sera of mothers with autistic children

HS Singer, CM Morris, CD Gause, PK Gillin…�- Journal of�…, 2008 - Elsevier
Serum antibodies in 100 mothers of children with autistic disorder (MCAD) were compared
to 100 age-matched mothers with unaffected children (MUC) using as antigenic substrates
human and rodent fetal and adult brain tissues, GFAP, and MBP. MCAD had significantly
more individuals with Western immunoblot bands at 36 kDa in human fetal and rodent
embryonic brain tissue. The density of bands was greater in fetal brain at 61 kDa. MCAD
plus developmental regression had greater reactivity against human fetal brain at 36 and 39�…
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