Neuroligin (NLG), a postsynaptic adhesion molecule, is involved in the formation of
synapses by binding to a cognate presynaptic ligand, neurexin. Here we report that
neuroligin-1 (NLG1) undergoes ectodomain shedding at the juxtamembrane stalk region to
generate a secreted form of NLG1 and a membrane-tethered C-terminal fragment (CTF) in
adult rat brains in vivo as well as in neuronal cultures. Pharmacological and genetic studies
identified ADAM10 as the major protease responsible for NLG1 shedding, the latter being�…

Activity-dependent proteolytic cleavage of Neuroligin-1 | CiNii Research … Activity-dependent
proteolytic cleavage of Neuroligin-1 … シナプス接着分子Neuroligin-1の神経活動依存的な
タンパク切断 …