This paper provides a comprehensive and systematic review of telemedicine use in autism spectrum disorder (ASD). A total of 36 articles met inclusion criteria and comprise the final study sample. A majority of the articles included in this review (33) are pilot studies, single-case designs, or case studies/case reports. Three surveys and one randomized controlled trial were also included. Included literature generally supports the feasibility and potential effectiveness of using telemedicine to increase access to autism evaluations and specialist expertise as well as to deliver a variety of interventions to individuals with ASD and/or their caregivers and families. However, methodological rigor in some studies is insufficient to support strong conclusions about impact. There is a need for larger, randomized trials to better determine impact.