Human mucin gene MUC5B is mapped clustered with MUC6, MUC2, and MUC5AC on
chromosome 11p15. 5. We report here the isolation of three overlapping genomic clones of�…

Iatrogenic tumorigenesis is a major limitation for the use of human induced pluripotent stem
cells (hiPSCs) in hematology. The teratoma risk comes from the persistence of hiPSCs in�…

Chemotherapies alter cellular redox balance and reactive oxygen species (ROS) content.
Recent studies have reported that chemoresistant cells have an increased oxidative state in�…

In 90% of people with erythropoietic protoporphyria (EPP), the disease results from the
inheritance of a common hypomorphic FECH allele, encoding ferrochelatase, in trans to a�…

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the infectious agent that
has caused the current coronavirus disease (COVID) pandemic. Viral infection relies on the�…

We have hypothesised that melanocytes disappear in vitiligo because they are weakly
attached to the epidermal basal membrane (melanocytorrhagy). In the epidermis�…

We previously reported that corticosteroid-binding globulin gene (Cbg) may be the causal
gene of a quantitative trait locus associated with cortisol levels, fat deposition, and muscle�…

Background Due to frequent mutations in certain cancers, FGFR3 gene is considered as an
oncogene. However, in some normal tissues, FGFR3 can limit cell growth and promote cell�…

Achieving long-term expression of a therapeutic gene in a given hematopoietic lineage
remains an important goal of gene therapy. Congenital erythropoietic porphyria (CEP) is a�…

Background Pancreatic ductal adenocarcinoma is a deadly malignancy resistant to current
therapies. It is critical to test new strategies, including tumor-targeted delivery of therapeutic�…