The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema�…

The acute respiratory distress syndrome (ARDS) causes 40% mortality in approximately
200,000 critically ill patients annually in the United States. ARDS is caused by protein-rich�…

The primary function of neutrophils in host defense is to contain and eradicate invading
microbial pathogens. This is achieved through a series of swift and highly coordinated�…

Sepsis, a systemic inflammatory response to infection, commonly progresses to acute lung
injury (ALI), an inflammatory lung disease with high morbidity. We postulated that sepsis�…

Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from impaired
regeneration of the alveolar epithelium after injury. During regeneration, type 2 alveolar�…

Injury to the epithelium is integral to the pathogenesis of many inflammatory lung diseases,
and epithelial repair is a critical determinant of clinical outcome. However, the signaling�…

A polymorphic C--> T transition located on the human Y chromosome was found by the
systematic comparative sequencing of Y-specific sequence-tagged sites by denaturing high�…

Advancements in methods, technology, and our understanding of the pathobiology of lung
injury have created the need to update the definition of experimental acute lung injury (ALI)�…

Many lung diseases result from a failure of efficient regeneration of damaged alveolar
epithelial cells (AECs) after lung injury. During regeneration, AEC2s proliferate to replace�…

Neutrophil influx into the extravascular compartments of the lungs is a defining characteristic
of the Acute Respiratory Distress Syndrome (ARDS). 1 During ARDS, circulating neutrophils�…