A considerable amount of knowledge has been produced during the last five years on the
bioenergetics of cancer cells, leading to a better understanding of the regulation of energy�…

We posit the following hypothesis: Independently of whether malignant tumors are initiated
by a fundamental reprogramming of gene expression or seeded by stem cells,“waves” of�…

With the extraordinary progress of mitochondrial science and cell biology, novel biochemical
pathways have emerged as strategic points of bioenergetic regulation and control. They�…

Mitochondria form a dynamic network, and it remains unclear how the alternate
configurations interact with bioenergetics properties. The metabolic signals that link�…

To investigate the physiological diversity in the regulation and control of mitochondrial
oxidative phosphorylation, we determined the composition and functional features of the�…

Little is known on the metabolic profile of lung tumors and the reminiscence of embryonic
features. Herein, we determined the bioenergetic profiles of human fibroblasts taken from�…

Background & Aims The cause of hepatic failure in the terminal stages of chronic injury is
unknown. Cellular metabolic adaptations in response to the microenvironment have been�…

Breast cancer cells can survive and proliferate under harsh conditions of nutrient
deprivation, including limited oxygen and glucose availability. We hypothesized that such�…

Anoikis resistance, or the ability for cells to live detached from the extracellular matrix, is a
property of epithelial cancers. The “Warburg effect,” or the preference of cancer cells for�…

Objective Autosomal recessive spastic ataxia of Charlevoix–Saguenay (ARSACS) is caused
by mutations in the SACS gene. SACS encodes sacsin, a protein whose function remains�…