Liraglutide is a glucagon-like peptide-1 (GLP-1) analog marketed for the treatment of type 2
diabetes. Besides lowering blood glucose, liraglutide also reduces body weight. It is not fully�…

Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum
albumin in vivo and is approved for once-daily treatment of diabetes as well as obesity. The�…

In recent years, analogs of human insulin have been engineered with the aim of improving
therapy for people with diabetes. To ensure that the safety profile of the human hormone is�…

In this publication we describe a peptide insulin receptor antagonist, S661, which is a single
chain peptide of 43 amino acids. The affinity of S661 for the insulin receptor is comparable to�…

The affinities of a number of insulin analogues for the human insulin receptor, a truncated
soluble form of the insulin receptor, and the human insulin‐like growth factor 1 receptor were�…

Pregnant women may be at higher risk of severe complications associated with the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical�…

Prophylactic oophorectomy during hysterectomy for benign disease has recently been
challenged1 using a Markov Decision Analysis. While this is appropriate from a�…

We have synthesized insulins acylated by fatty acids in the ε-amino group of Lys B29.
Soluble preparations can be made in the usual concentration of 600 nmol/ml (100 IU/ml) at�…

Alanine scanning mutagenesis has been used to identify specific side chains of insulin
which strongly influence binding to the insulin receptor. A total of 21 new insulin analog�…

The glucagon-like peptide-1 incretin receptor (GLP-1R) of family BG protein-coupled
receptors (GPCRs) is a major drug target in type-2-diabetes due to its regulatory effect on�…