In vitro generation and expansion of hematopoietic stem cells (HSCs) holds great promise
for the treatment of any ailment that relies on bone marrow or blood transplantation. To�…

Cytosolic DNA promotes inflammatory responses upon detection by the cyclic GMP‐AMP
(cGAMP) synthase (cGAS). It has been suggested that cGAS downregulation is an immune�…

The inability to control cell proliferation results in the formation of tumors in many
multicellular lineages. Nonetheless, little is known about the extent of conservation of the�…

While it is often assumed that oncogenic processes in metazoans can influence species
interactions, empirical evidence is lacking. Here, we use the cnidarian Hydra oligactis to�…

Microtubules are structural components of the cell cytoskeleton and key factors for mitosis
and ciliogenesis in eukaryotes. The regulation of MT dynamics requires non-motor MAPs�…

Zebrafish is widely adopted as a grafting model for studying human development and
diseases. Current zebrafish xenotransplantations are performed using embryo recipients, as�…

Germline mutations that activate genes in the canonical RAS/MAPK signaling pathway are
responsible for rare human developmental disorders known as RASopathies. Here, we�…

Cancer is a disease that affects the control of cell proliferation in many multicellular lineages.
Nonetheless, little is known about the extent of conservation of the biological traits and�…

Recently, many studies demonstrated the fundamental role of the tumour microenvironment
(TME) in cancer progression. Here, we describe a method to visualize in 3D the behaviour of�…

The peripheral nervous system has a key role in regulating tumour biology in different types
of cancer. Here, by modelling aggressive melanoma in larval zebrafish xenografts, we�…