Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular�…

The acronym CHARGE refers to a syndrome of unknown cause. Here we report on 47
CHARGE patients evaluated for the frequency of major anomalies, namely coloboma (79%)�…

BACKGROUND: Assessment of the change in tumour burden is an important feature of the
clinical evaluation of cancer therapeutics: both tumour shrinkage (objective response) and�…

Thrombosis results from the interaction between predisposing genetic polymorphisms and
acquired risk factors. Two of the main prothrombotic alleles, Factor V (FV) Leiden and�…

In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that
LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass�…

Background Glioblastoma, the most common primary brain tumor in adults, is usually rapidly
fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to�…

Background In 2004, a randomised phase III trial by the European Organisation for
Research and Treatment of Cancer (EORTC) and National Cancer Institute of Canada�…

Aicardi-Gouti�res syndrome (AGS) is an autosomal recessive neurological disorder, the
clinical and immunological features of which parallel those of congenital viral infection. Here�…

The tumour suppressor gene PTEN, which maps to 10q23. 3 and encodes a 403 amino acid
dual specificity phosphatase (protein tyrosine phosphatase; PTPase), was shown recently to�…

Purpose Anaplastic oligodendroglioma are chemotherapy-sensitive tumors. We now present
the long-term follow-up findings of a randomized phase III study on the addition of six cycles�…