Abstract Forkhead box P3 (FOXP3)+ regulatory T (TReg) cells are potent mediators of
dominant self tolerance in the periphery. But confusion as to the identity, stability and�…

In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and�…

Oral tolerance is a long recognized method to induce peripheral immune tolerance. The
primary mechanisms by which orally administered antigen induces tolerance are via the�…

CD4+ CD25+ regulatory T cells contribute to the maintenance of peripheral tolerance by
active suppression because their deletion causes spontaneous autoimmune diseases in�…

There has been a marked increase in the incidence of autoimmune diseases in the past half-
century. Although the underlying genetic basis of this class of diseases has recently been�…

Thymectomy in mice on neonatal day 3 leads to the development of multiorgan autoimmune
disease due to loss of a CD+ CD25+ T cell regulatory population in their peripheral�…

Abstract CD4+ CD25highCD127low/–forkhead box p3 (Foxp3)+ regulatory T cells (Treg
cells) possess functional plasticity. Here we describe a higher frequency of T helper type 1�…

Experimental autoimmune encephalomyelitis (EAE) is a cell-mediated autoimmune disease
that serves as an animal model for multiple sclerosis. Oral administration of myelin basic�…

Multiple sclerosis (MS) is thought to be an autoimmune disease mediated by T lymphocytes
that recognize myelin components of the central nervous system. In a 1-year double-blind�…

CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by
numerous pathways, including the negative immune receptor Tim-3. We found that Tim-3 is�…