Two classes of intracellular Ca 2+-release channels, the ryanodine reccptor and the mositol
(1, 4, 5)-trisphosphate (IP 3) receptor, are essential for spatiotemporal Ca 2+ signalling in�…

Signaling pathways regulate contraction of striated (skeletal and cardiac) and smooth
muscle. Although these are similar, there are striking differences in the pathways that can be�…

Chemotherapy is a life‐saving treatment for cancer patients, but also causes long‐term
cognitive impairment, or “chemobrain”, in survivors. However, several challenges, including�…

RELEASE of calcium from intracellular stores occurs by two pathways, an inositol 1, 4, 5-
trisphosphate (InsP3)-gated channel1–3 and a calcium-gated channel (ryanodine receptor)�…

Abstract Inositol 1, 4, 5-trisphosphate (InsP3) can initiate calcium release into the cytoplasm
in a variety of cells1, 2. From experiments using permeabilized cells3, 4, membrane�…

Abstract The inositol 1, 4, 5-trisphosphate receptor (InsP3R) is the main calcium (Ca2+)
release channel in most tissues. Three isoforms have been identified,,,,,, but only types I and�…

Abstract FK506-binding protein (FKBP12) was originally identified as the cytosolic receptor
for the immunosuppressant drugs FK506 and rapamycin. The cellular function of FKBP12, a�…

Polycystin-2, the product of the gene mutated in type 2 autosomal dominant polycystic
kidney disease (ADPKD), is the prototypical member of a subfamily of the transient receptor�…

Taxol (Paclitaxel) is an important natural product for the treatment of solid tumors. Despite a
well documented tubulin-stabilizing effect, many side effects of taxol therapy cannot be�…

Regulation and dysregulation of intracellular calcium (Ca2+) signaling via the inositol 1, 4, 5-
trisphosphate receptor (InsP3R) has been linked to many cellular processes and�…