Anandamide and 2-arachidonoylglycerol differentially modulate autistic-like traits in a genetic model of autism based on FMR1 deletion in rats

S Schiavi, A Manduca, E Carbone, V Buzzelli…�- …, 2023 - nature.com
Autism spectrum disorder (ASD) has a multifactorial etiology. Major efforts are underway to
understand the neurobiological bases of ASD and to develop efficacious treatment�…

Targeting the inhibition of fatty acid amide hydrolase ameliorate the endocannabinoid-mediated synaptic dysfunction in a valproic acid-induced rat model of Autism

HF Wu, TY Lu, MC Chu, PS Chen, CW Lee, HC Lin�- Neuropharmacology, 2020 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, characterized by social
interaction impairment, stereotypical/repetitive behaviors and emotional deregulation. The�…

Alterations of the endocannabinoid system and its therapeutic potential in autism spectrum disorder

M Zou, Y Liu, S Xie, L Wang, D Li, L Li…�- Open�…, 2021 - royalsocietypublishing.org
Autism spectrum disorder (ASD) is a group of developmental disabilities, the aetiology of
which remains elusive. The endocannabinoid (eCB) system modulates neurotransmission�…

The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: Lessons from behavioral studies on mouse models

S Pietropaolo, G Marsicano�- Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Recent years have seen an impressive amount of research devoted to understanding the
etiopathology of Autism Spectrum Disorder (ASD) and developing therapies for this�…

The role of the endocannabinoid system in autism spectrum disorders: Evidence from mouse studies

S Pietropaolo, L Bellocchio, I Bouz�n-Arn�iz…�- Progress in Molecular�…, 2020 - Elsevier
A substantive volume of research on autism spectrum disorder (ASD) has emerged in recent
years adding to our understanding of the etiopathological process. Preclinical models in�…

[HTML][HTML] Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid

M Servadio, F Melancia, A Manduca, A Di Masi…�- Translational�…, 2016 - nature.com
Autism spectrum disorders (ASD) are characterized by altered sociability, compromised
communication and stereotyped/repetitive behaviors, for which no specific treatments are�…

Endocannabinoid markers in autism spectrum disorder: a scoping review of human studies

M De Pol, NJ Kolla�- Psychiatry Research, 2021 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social
communication deficits and patterns of restrictive and repetitive behavior. Although the�…

Enhancement of anandamide-mediated endocannabinoid signaling corrects autism-related social impairment

D Wei, D Dinh, DY Lee, D Li, A Anguren…�- Cannabis and�…, 2016 - liebertpub.com
Introduction: We recently uncovered a signaling mechanism by which the endocannabinoid
anandamide mediates the action of oxytocin, a neuropeptide that is crucial for social�…

Pharmacological inhibition of the primary endocannabinoid producing enzyme, DGL‐α, induces autism spectrum disorder‐like and co‐morbid phenotypes in adult�…

W Fyke, JM Alarcon, M Velinov…�- Autism Research, 2021 - Wiley Online Library
Accumulating evidence links dysfunction in the endocannabinoid system (ECS) with the
pathology of neurodevelopmental disorders, particularly autism spectrum disorder (ASD)�…

[HTML][HTML] Increased 2-arachidonoyl-sn-glycerol levels normalize cortical responses to sound and improve behaviors in Fmr1 KO mice

PS Pirbhoy, CR Jonak, R Syed, DA Argueta…�- Journal of�…, 2021 - Springer
Abstract Background Individuals with Fragile X syndrome (FXS) and autism spectrum
disorder (ASD) exhibit an array of symptoms, including sociability deficits, increased anxiety�…