[HTML][HTML] Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders

L Rojas-Charry, L Nardi, A Methner…�- Journal of Molecular�…, 2021 - Springer
Autism spectrum disorder (ASD) is a neurodevelopmental condition primarily characterized
by an impairment of social interaction combined with the occurrence of repetitive behaviors�…

[HTML][HTML] The mitochondrial dysfunction hypothesis in autism spectrum disorders: current status and future perspectives

L Citrigno, M Muglia, A Qualtieri, P Spadafora…�- International journal of�…, 2020 - mdpi.com
Autism spectrum disorders (ASDs) constitute a set of heterogeneous neurodevelopmental
conditions, characterized by a wide genetic variability that has led to hypothesize a�…

[HTML][HTML] Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders

RE Frye, DA Rossignol�- Pediatric research, 2011 - nature.com
Autism spectrum disorder (ASD) is a devastating neurodevelopmental disorder. Over the
past decade, evidence has emerged that some children with ASD suffer from undiagnosed�…

Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives

F Hollis, AK Kanellopoulos, C Bagni�- Current opinion in neurobiology, 2017 - Elsevier
Highlights•Numerous clinical studies highlight mitochondrial involvement in ASD.•Brain
mitochondrial function needs attention at the synaptic level.•Functional studies needed to�…

[HTML][HTML] Clinical and molecular characteristics of mitochondrial dysfunction in autism spectrum disorder

S Rose, DM Niyazov, DA Rossignol…�- Molecular diagnosis &�…, 2018 - Springer
Autism spectrum disorder (ASD) affects~ 2% of children in the United States. The etiology of
ASD likely involves environmental factors triggering physiological abnormalities in�…

Mitochondrial etiology of neuropsychiatric disorders

L Pei, DC Wallace�- Biological psychiatry, 2018 - Elsevier
The brain has the highest mitochondrial energy demand of any organ. Therefore, subtle
changes in mitochondrial energy production will preferentially affect the brain. Considerable�…

[HTML][HTML] Metabolic dysfunction underlying autism spectrum disorder and potential treatment approaches

N Cheng, JM Rho, SA Masino�- Frontiers in molecular neuroscience, 2017 - frontiersin.org
Autism spectrum disorder (ASD) is characterized by deficits in sociability and
communication, and increased repetitive and/or restrictive behaviors. While the etio�…

Evidence of mitochondrial dysfunction in autism: Biochemical links, genetic‐based associations, and non‐energy‐related mechanisms

KK Griffiths, RJ Levy�- Oxidative medicine and cellular longevity, 2017 - Wiley Online Library
Autism spectrum disorder (ASD), the fastest growing developmental disability in the United
States, represents a group of neurodevelopmental disorders characterized by impaired�…

Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: an overview of Down syndrome, autism, Fragile X and Rett syndrome

D Valenti, L de Bari, B De Filippis…�- Neuroscience &�…, 2014 - Elsevier
Clinical manifestations typical of mitochondrial diseases are often present in various genetic
syndromes associated with intellectual disability, a condition leading to deficit in cognitive�…

Mitochondrial dysfunction: a common denominator in neurodevelopmental disorders?

XR Ortiz-Gonz�lez�- Developmental neuroscience, 2021 - karger.com
Mitochondria, the organelles classically seen as the powerhouse of the cell, are increasingly
associated with a wide variety of neurodevelopmental disorders. Although individually rare�…