Social isolation during opioid withdrawal is a major contributor to the current opioid
addiction crisis. We find that sociability deficits during protracted opioid withdrawal in mice�…

Addiction is a chronic disorder involving recurring intoxication, withdrawal, and craving
episodes. Escaping this vicious cycle requires maintenance of abstinence for extended�…

Endogenous opioid systems have been implicated in the consequences of social isolation
and in the regulation of social behavior, although their precise role is not clear. There is not�…

Accumulating evidence indicates that kappa-opioid receptors (KORs) and their endogenous
ligand, dynorphin (DYN), can play important roles in regulating the effects of stress. Here, we�…

Until recently, most modern neuroscience research on addiction using animal models did
not incorporate manipulations of social factors. Social factors play a critical role in human�…

Previous studies have demonstrated that repeated forced-swim stress-induced behaviors
(including analgesia, immobility, and increased drug reward) were mediated by the release�…

The prairie vole is a socially monogamous species in which breeder pairs typically show
strong and selective pair bonds. The establishment of a pair bond is associated with a�…

Following repeated opioid use, some dependent individuals experience persistent cognitive
deficits that contribute to relapse of drug-taking behaviors, and one component of this�…

Drug addiction has devastating consequences on social behaviors and can lead to the
impairment of social bonding. Accumulating evidence indicates that alterations in oxytocin�…

Behavioral, biological, and social sequelae that lead to drug addiction differ between men
and women. Our efforts to understand addiction on a mechanistic level must include studies�…