[HTML][HTML] Deletion of the autism-associated protein SHANK3 abolishes structural synaptic plasticity after brain trauma
C Urrutia-Ruiz, D Rombach, S Cursano…�- International journal of�…, 2022 - mdpi.com
Autism spectrum disorders (ASDs) are characterized by repetitive behaviors and
impairments of sociability and communication. About 1% of ASD cases are caused by�…
impairments of sociability and communication. About 1% of ASD cases are caused by�…
Defective synapse maturation and enhanced synaptic plasticity in shank2 Δex7–/–mice
Autism spectrum disorders (ASDs) are neurodevelopmental disorders with a strong genetic
etiology. Since mutations in human SHANK genes have been found in patients with autism�…
etiology. Since mutations in human SHANK genes have been found in patients with autism�…
[HTML][HTML] Autism-like deficits in Shank3-deficient mice are rescued by targeting actin regulators
Haploinsufficiency of the Shank3 gene, which encodes a scaffolding protein at glutamatergic
synapses, is a highly prevalent and penetrant risk factor for autism. Using combined�…
synapses, is a highly prevalent and penetrant risk factor for autism. Using combined�…
Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4‐9 Deletion Mouse Model of Autism
TC Jaramillo, HE Speed, Z Xuan, JM Reimers…�- Autism�…, 2016 - Wiley Online Library
Shank3 is a multi‐domain, synaptic scaffolding protein that organizes proteins in the
postsynaptic density of excitatory synapses. Clinical studies suggest that∼ 0.5% of autism�…
postsynaptic density of excitatory synapses. Clinical studies suggest that∼ 0.5% of autism�…
[HTML][HTML] Gene Dosage- and Age-Dependent Differential Transcriptomic Changes in the Prefrontal Cortex of Shank2-Mutant Mice
Shank2 is an abundant postsynaptic scaffolding protein that is known to regulate excitatory
synapse assembly and synaptic transmission and has been implicated in various�…
synapse assembly and synaptic transmission and has been implicated in various�…
[HTML][HTML] Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
O Bozdagi, T Sakurai, D Papapetrou, X Wang…�- Molecular autism, 2010 - Springer
Background SHANK3 is a protein in the core of the postsynaptic density (PSD) and has a
critical role in recruiting many key functional elements to the PSD and to the synapse�…
critical role in recruiting many key functional elements to the PSD and to the synapse�…
[HTML][HTML] Altered Behaviors and Impaired Synaptic Function in a Novel Rat Model With a Complete Shank3 Deletion
TJ Song, XY Lan, MP Wei, FJ Zhai…�- Frontiers in Cellular�…, 2019 - frontiersin.org
Mutations within the Shank3 gene, which encodes a key postsynaptic density (PSD) protein
at glutamatergic synapses, contribute to the genetic etiology of defined autism spectrum�…
at glutamatergic synapses, contribute to the genetic etiology of defined autism spectrum�…
[HTML][HTML] Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats
S Jacot-Descombes, NU Keshav, DL Dickstein…�- Molecular Autism, 2020 - Springer
Background Deletion or mutations of SHANK3 lead to Phelan–McDermid syndrome and
monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous�…
monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous�…
Cell-type-specific Shank2 deletion in mice leads to differential synaptic and behavioral phenotypes
Shank2 is an excitatory postsynaptic scaffolding protein implicated in synaptic regulation
and psychiatric disorders including autism spectrum disorders. Conventional Shank2-mutant�…
and psychiatric disorders including autism spectrum disorders. Conventional Shank2-mutant�…
[HTML][HTML] Altered spinogenesis in iPSC-derived cortical neurons from patients with autism carrying de novo SHANK3 mutations
L Gouder, A Vitrac, H Goubran-Botros, A Danckaert…�- Scientific reports, 2019 - nature.com
The synaptic protein SHANK3 encodes a multidomain scaffold protein expressed at the
postsynaptic density of neuronal excitatory synapses. We previously identified de novo�…
postsynaptic density of neuronal excitatory synapses. We previously identified de novo�…