Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila
L Worpenberg, C Paolantoni, S Longhi…�- The EMBO�…, 2021 - embopress.org
Abstract N6‐methyladenosine (m6A) regulates a variety of physiological processes through
modulation of RNA metabolism. This modification is particularly enriched in the nervous�…
modulation of RNA metabolism. This modification is particularly enriched in the nervous�…
[HTML][HTML] FMRP modulates neural differentiation through m6A-dependent mRNA nuclear export
Summary N 6-methyladenosine (m 6 A) modification of mRNA is emerging as a vital
mechanism regulating RNA function. Here, we show that fragile X mental retardation protein�…
mechanism regulating RNA function. Here, we show that fragile X mental retardation protein�…
The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila
J Leismann, M Spagnuolo, M Pradhan, L Wacheul…�- EMBO�…, 2020 - embopress.org
RNA modifications have recently emerged as an important layer of gene regulation. N6‐
methyladenosine (m6A) is the most prominent modification on eukaryotic messenger RNA�…
methyladenosine (m6A) is the most prominent modification on eukaryotic messenger RNA�…
[HTML][HTML] A neural m6A/Ythdf pathway is required for learning and memory in Drosophila
Epitranscriptomic modifications can impact behavior. Here, we used Drosophila
melanogaster to study N6-methyladenosine (m6A), the most abundant modification of�…
melanogaster to study N6-methyladenosine (m6A), the most abundant modification of�…
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets
Abstract N 6-methyladenosine (m6A) is the most prevalent internal modification of
mammalian messenger RNAs (mRNAs) and long non-coding RNAs. The biological�…
mammalian messenger RNAs (mRNAs) and long non-coding RNAs. The biological�…
[HTML][HTML] The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine–containing mRNAs
N 6-Methyladenosine (m 6 A) is the most abundant post-transcriptional mRNA modification
in eukaryotes and exerts many of its effects on gene expression through reader proteins that�…
in eukaryotes and exerts many of its effects on gene expression through reader proteins that�…
[HTML][HTML] Fmrp interacts with adar and regulates RNA editing, synaptic density and locomotor activity in zebrafish
A Shamay-Ramot, K Khermesh, HT Porath…�- PLoS�…, 2015 - journals.plos.org
Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The
cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1)�…
cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1)�…
Dynamic m6A modification regulates local translation of mRNA in axons
J Yu, M Chen, H Huang, J Zhu, H Song…�- Nucleic acids�…, 2018 - academic.oup.com
Abstract N 6-methyladenosine (m6A) is a reversible modification in mRNA and has been
shown to regulate processing, translation and decay of mRNA. However, the roles of m6A�…
shown to regulate processing, translation and decay of mRNA. However, the roles of m6A�…
Transcriptome‐wide analysis of N6‐methyladenosine uncovers its regulatory role in gene expression in the lepidopteran Bombyx mori
B Li, X Wang, Z Li, C Lu, Q Zhang…�- Insect Molecular�…, 2019 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) methylation is the most common form of RNA
modification in eukaryotes and has been shown to act as an important epitranscriptomic�…
modification in eukaryotes and has been shown to act as an important epitranscriptomic�…
[HTML][HTML] Mettl3-dependent m6A modification attenuates the brain stress response in Drosophila
AE Perlegos, EJ Shields, H Shen, KF Liu…�- Nature�…, 2022 - nature.com
Abstract N 6-methyladenosine (m6A), the most prevalent internal modification on eukaryotic
mRNA, plays an essential role in various stress responses. The brain is uniquely vulnerable�…
mRNA, plays an essential role in various stress responses. The brain is uniquely vulnerable�…