Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction
Despite an estimated heritability of~ 50%, genome-wide association studies of opioid use
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross�…
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross�…
[HTML][HTML] Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond
N Gaddis, R Mathur, J Marks, L Zhou, B Quach…�- Scientific reports, 2022 - nature.com
Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in
OPRM1, has been identified as a genome-wide significant association with OA and�…
OPRM1, has been identified as a genome-wide significant association with OA and�…
Association of OPRM1 functional coding variant with opioid use disorder: a genome-wide association study
Importance With the current opioid crisis, it is important to improve understanding of the
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk�…
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk�…
Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium
R Polimanti, RK Walters, EC Johnson…�- Molecular�…, 2020 - nature.com
To provide insights into the biology of opioid dependence (OD) and opioid use (ie,
exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173�…
exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173�…
[HTML][HTML] Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent�…
Despite the large toll of opioid use disorder (OUD), genome-wide association studies
(GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale�…
(GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale�…
[HTML][HTML] Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry
S Sanchez-Roige, P Fontanillas, MV Jennings…�- Molecular�…, 2021 - nature.com
The growing prevalence of opioid use disorder (OUD) constitutes an urgent health crisis.
Ample evidence indicates that risk for OUD is heritable. As a surrogate (or proxy) for OUD�…
Ample evidence indicates that risk for OUD is heritable. As a surrogate (or proxy) for OUD�…
[HTML][HTML] Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use�…
Background Prevalence rates of opioid use disorder (OUD) have increased dramatically,
accompanied by a surge of overdose deaths. While opioid dependence has been�…
accompanied by a surge of overdose deaths. While opioid dependence has been�…
A review of opioid addiction genetics
RC Crist, BC Reiner, WH Berrettini�- Current opinion in psychology, 2019 - Elsevier
Highlights•Opioid use disorder risk has a large heritable component (23–54%).•The OPRM1
variant rs1799971 (aka A118G) as a small effect on risk for OUD and general substance�…
variant rs1799971 (aka A118G) as a small effect on risk for OUD and general substance�…
Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways
Background We report a genome-wide association study (GWAS) of two populations, African-
American and European-American (AA, EA) for opioid dependence (OD) in three sets of�…
American and European-American (AA, EA) for opioid dependence (OD) in three sets of�…
[HTML][HTML] Molecular imaging of opioid and dopamine systems: insights into the pharmacogenetics of opioid use disorders
JA Burns, DS Kroll, DE Feldman, C Kure Liu…�- Frontiers in�…, 2019 - frontiersin.org
Opioid use in the United States has steadily risen since the 1990s, along with staggering
increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid�…
increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid�…
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