[HTML][HTML] Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome
Epidemiological studies suggest that individuals with neurodevelopmental disorders (NDDs)
are more prone to develop certain types of cancer. Notably, however, the case statistics can�…
are more prone to develop certain types of cancer. Notably, however, the case statistics can�…
Autism and cancer share risk genes, pathways, and drug targets
JN Crawley, WD Heyer, JM LaSalle�- Trends in Genetics, 2016 - cell.com
Autism is a neurodevelopmental disorder, diagnosed behaviorally by social and
communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide�…
communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide�…
New gene discoveries highlight functional convergence in autism and related neurodevelopmental disorders
Highlights•Exome sequencing on unprecedented scale has identified 400 genes associated
with ASD and NDD.•Functional networks disrupted in NDD converge on distinct�…
with ASD and NDD.•Functional networks disrupted in NDD converge on distinct�…
[HTML][HTML] Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies
N Murtaza, AA Cheng, CO Brown, DP Meka, S Hong…�- Cell Reports, 2022 - cell.com
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but
signaling networks at the protein level remain unexplored. We use neuron-specific proximity�…
signaling networks at the protein level remain unexplored. We use neuron-specific proximity�…
[HTML][HTML] Connecting the dots: Overlaps between autism and cancer suggest possible common mechanisms regarding signaling pathways related to metabolic�…
Y Wen, MR Herbert�- Medical hypotheses, 2017 - Elsevier
Common features between autism spectrum disorders (ASDs) and cancer have been
discerned using methodologies from a number of disciplines, including genetics�…
discerned using methodologies from a number of disciplines, including genetics�…
De novo mutation of cancer-related genes associates with particular neurodevelopmental disorders
B Li, K Li, D Tian, Q Zhou, Y Xie, Z Fang…�- Journal of Molecular�…, 2020 - Springer
Epidemiological studies have shown an increased prevalence of cancer in some patients
with neurodevelopmental disorder (NDD); however, the genetic mechanisms regarding how�…
with neurodevelopmental disorder (NDD); however, the genetic mechanisms regarding how�…
[HTML][HTML] Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer
J For�s-Martos, F Catal�-L�pez, J S�nchez-Valle…�- Molecular autism, 2019 - Springer
Background Epidemiological and clinical evidence points to cancer as a comorbidity in
people with autism spectrum disorders (ASD). A significant overlap of genes and biological�…
people with autism spectrum disorders (ASD). A significant overlap of genes and biological�…
Autism genetics perturb prenatal neurodevelopment through a hierarchy of broadly-expressed and brain-specific genes
Numerous genes are associated with autism spectrum disorder (ASD); however, it remains
unclear how most ASD risk genes influence neurodevelopment and result in similar traits�…
unclear how most ASD risk genes influence neurodevelopment and result in similar traits�…
Protein interactome reveals converging molecular pathways among autism disorders
To uncover shared pathogenic mechanisms among the highly heterogeneous autism
spectrum disorders (ASDs), we developed a protein interaction network that identified�…
spectrum disorders (ASDs), we developed a protein interaction network that identified�…
[HTML][HTML] Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders
Abstract “Big data” approaches in the form of large-scale human genomic studies have led
to striking advances in autism spectrum disorder (ASD) genetics. Similar to many other�…
to striking advances in autism spectrum disorder (ASD) genetics. Similar to many other�…