Recent evidence has documented the potential roles of histone-modifying enzymes in
autism-spectrum disorder (ASD). Aberrant histone H3 lysine 9 (H3K9) dimethylation�…

Background Histone H3 methylation at lysine 9 (H3K9) is a conserved epigenetic signal,
mediating heterochromatin formation by trimethylation, and transcriptional silencing by�…

Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational
modification, which is broadly associated with enhancers and promoters of actively�…

Significant neurological disorders can result from subtle perturbations of gene regulation
that are often linked to epigenetic regulation. Proteins that regulate the methylation of lysine�…

Disruptive mutations in the chromodomain helicase DNA-binding protein 8 gene (CHD8)
have been recurrently associated with autism spectrum disorders (ASDs). Here we�…

Many of the genes disrupted in autism are identified as histone-modifying enzymes and
chromatin remodelers, most prominently those that mediate histone methylation�…

Large-scale genetic studies have revealed that the most prominent genes disrupted in
autism are chromatin regulators mediating histone methylation/demethylation, suggesting�…

Recent studies have consistently demonstrated that the regulation of chromatin and gene
transcription plays a pivotal role in the pathogenesis of neurodevelopmental disorders�…

Kleefstra syndrome, caused by haploinsufficiency of euchromatin histone methyltransferase
1 (EHMT1), is characterized by intellectual disability (ID), autism spectrum disorder (ASD)�…

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders that cause
severe social, communication, and behavioral problems. Recent studies show that the�…