[HTML][HTML] Optogenetic activation of striatal D1R and D2R cells differentially engages downstream connected areas beyond the basal ganglia
The basal ganglia (BG) are a group of subcortical nuclei responsible for motor and executive
function. Central to BG function are striatal cells expressing D1 (D1R) and D2 (D2R)�…
function. Central to BG function are striatal cells expressing D1 (D1R) and D2 (D2R)�…
[HTML][HTML] Optogenetic activation of A11 region increases motor activity
K Koblinger, C Jean-Xavier, S Sharma…�- Frontiers in neural�…, 2018 - frontiersin.org
Limbic brain regions drive goal-directed behaviors. These behaviors often require dynamic
motor responses, but the functional connectome of limbic structures in the diencephalon that�…
motor responses, but the functional connectome of limbic structures in the diencephalon that�…
Dopamine D1 receptor-mediated transmission maintains information flow through the cortico-striato-entopeduncular direct pathway to release movements
S Chiken, A Sato, C Ohta, M Kurokawa, S Arai…�- Cerebral�…, 2015 - academic.oup.com
In the basal ganglia (BG), dopamine plays a pivotal role in motor control, and dopamine
deficiency results in severe motor dysfunctions as seen in Parkinson's disease. According to�…
deficiency results in severe motor dysfunctions as seen in Parkinson's disease. According to�…
[HTML][HTML] Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum
E Puighermanal, L Castell, A Esteve-Codina…�- Nature�…, 2020 - nature.com
Action control is a key brain function determining the survival of animals in their
environment. In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal�…
environment. In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal�…
It takes two to tango: Dorsal direct and indirect pathways orchestration of motor learning and behavioral flexibility
P Bonnavion, EP Fern�ndez, C Varin…�- Neurochemistry�…, 2019 - Elsevier
The striatum as the main entry nucleus of the basal ganglia is long known to be critical for
motor control. It integrates information from multiple cortical areas, thalamic and midbrain�…
motor control. It integrates information from multiple cortical areas, thalamic and midbrain�…
[HTML][HTML] Dopamine gates visual signals in monkey prefrontal cortex neurons
M Stalter, S Westendorff, A Nieder�- Cell reports, 2020 - cell.com
The neurotransmitter dopamine, which acts via the D1-like receptor (D1R) and D2-like
receptor (D2R) family, may play an important role in gating sensory information to the�…
receptor (D2R) family, may play an important role in gating sensory information to the�…
D1 receptor modulation of action potential firing in a subpopulation of layer 5 pyramidal neurons in the prefrontal cortex
HJ Seong, AG Carter�- Journal of Neuroscience, 2012 - Soc Neuroscience
Dopamine modulation in the prefrontal cortex is important for cognitive processing and
disrupted in diverse neuropsychiatric diseases. Activation of D1 receptors is thought to�…
disrupted in diverse neuropsychiatric diseases. Activation of D1 receptors is thought to�…
Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens
L Tritschler, MA Kheirbek, Y Le Dantec…�- Neuroscience�…, 2018 - Elsevier
The dentate gyrus (DG) has distinct roles along its dorso-ventral axis. In the mouse, we
recently demonstrated that dorsal DG (dDG) stimulation enhances exploratory behavior�…
recently demonstrated that dorsal DG (dDG) stimulation enhances exploratory behavior�…
Dopamine D2 receptors modulate pyramidal neurons in mouse medial prefrontal cortex through a stimulatory G-protein pathway
SE Robinson, VS Sohal�- Journal of Neuroscience, 2017 - Soc Neuroscience
Dopaminergic modulation of prefrontal cortex (PFC) is thought to play key roles in many
cognitive functions and to be disrupted in pathological conditions, such as schizophrenia�…
cognitive functions and to be disrupted in pathological conditions, such as schizophrenia�…
[HTML][HTML] A non-canonical striatopallidal Go pathway that supports motor control
In the classical model of the basal ganglia, direct pathway striatal projection neurons
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to�…
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to�…