The aim of this work was to establish an organ model for staphylococcal infection of human
bone samples and to investigate the influence and efficacy of a microporous β-tricalcium�…

Differences in physico-chemical characteristics of bone grafts to fill bone defects have been
demonstrated to influence in vitro bacterial biofilm formation. Aim of the study was to�…

The purpose of the present work was to evaluate in vivo different antimicrobial therapies to
eradicate osteomyelitis created in the femoral head of New Zealand rabbits. Five phosphate�…

Infections after bone reconstructive surgery are a real therapeutic and economic issue for
the modern health care system. As the pathogen (most often Staphylococcus aureus) is able�…

The treatment of bone infections has always been difficult. The emergence of drug-resistant
bacteria has led to a steady decline in the effectiveness of antibiotics. It is also especially�…

Bone tissue infection is a major clinical challenge with high morbidity and a significant
healthcare burden. Therapeutic approaches are usually based on systemic antibacterial�…

Even though the systemic antibiotic therapy is usually applied after prosthetic infections
surgical treatments, it is unable to reach the infection site in sufficient concentrations to�…

Increased use of implantable biomedical devices demonstrates their potential in treating a
wide variety of ailments and disorders in bone trauma and orthopaedic, reconstructive, and�…

Open fractures are at risk of serious infection and, if infected, require several surgical
interventions and courses of systemic antibiotics. We investigated a new injectable�…

Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its
high recurrence rate and impaired restoration of bone deficiencies are major challenges in�…