Unrelated genetic mutations can lead to convergent manifestations of neurological disorders
with similar behavioral phenotypes. Experimental data frequently show a lack of dramatic�…

Throughout development, the brain transits from early highly synchronous activity patterns to
a mature state with sparse and decorrelated neural activity, yet the mechanisms underlying�…

The prefrontal cortex (PFC) is involved in cognitive tasks such as working memory, decision
making, risk assessment and regulation of attention. These functions performed by the PFC�…

Proper brain function requires stringent balance of excitatory and inhibitory synapse
formation during neural circuit assembly. Mutation of genes that normally sculpt and�…

Many neurodevelopmental and neuropsychiatric disorders involve an imbalance between
excitation and inhibition caused by synaptic alterations. The proper excitation/inhibition (E/I)�…

A tight balance between excitation and inhibition (E/I balance) in synaptic inputs to a neuron
and in neural circuits is important for correct brain development and function. E/I imbalances�…

In the context of neurophysiology, balance of excitation and inhibition (E/I balance) refers to
the relative contributions of excitatory and inhibitory synaptic inputs corresponding to some�…

Throughout development, the brain transits from early highly synchronous activity patterns to
a mature state with sparse and decorrelated neural activity, yet the mechanisms underlying�…

Excitatory/inhibitory (E/I) balance, defined as the balance between excitation and inhibition
of synaptic activity in a neuronal network, accounts in part for the normal functioning of the�…

Recent advances in genomics have revealed a wide spectrum of genetic variants
associated with neurodevelopmental disorders at an unprecedented scale. An increasing�…