Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor

EA Fink, J Xu, H H�bner, JM Braz, P Seemann, C Avet…�- Science, 2022 - science.org
Because nonopioid analgesics are much sought after, we computationally docked more
than 301 million virtual molecules against a validated pain target, the α2A-adrenergic�…
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Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor.

EA Fink, J Xu, H H�bner, JM Braz, P Seemann, C Avet…�- Science, 2022 - escholarship.org
Because nonopioid analgesics are much sought after, we computationally docked more
than 301 million virtual molecules against a validated pain target, the α2A-adrenergic�…
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Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor

EA Fink, J Xu, H H�bner, JM Braz, P Seemann, C Avet…�- Science, 2022 - cdr.lib.unc.edu
Because nonopioid analgesics are much sought after, we computationally docked more
than 301 million virtual molecules against a validated pain target, the α2A-adrenergic�…
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[HTML][HTML] Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor

EA Fink, J Xu, H H�bner, JM Braz…�- Science (New York�…, 2022 - ncbi.nlm.nih.gov
Because nonopioid analgesics are much sought after, we computationally docked more
than 301 million virtual molecules against a validated pain target, the α 2A-adrenergic�…
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[PDF][PDF] Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor

EA Fink, J Xu, H H�bner, JM Braz, P Seemann, C Avet…�- Science, 2022 - drive.google.com
RESULTS: From the high-ranking docked compounds, we selected 48 for de novo synthesis
and testing. Against the a2BAR used in the virtual docking screens, 30 molecules bound for�…
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Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor

EA Fink, J Xu, H H�bner, JM Braz, P Seemann, C Avet… - paper.sciencenet.cn
Because nonopioid analgesics are much sought after, we computationally docked more
than 301 million virtual molecules against a validated pain target, the α2A-adrenergic�…
Cite

Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor

EA Fink, J Xu, H H�bner, JM Braz…�- …�(New York, NY), 2022 - pubmed.ncbi.nlm.nih.gov
Because nonopioid analgesics are much sought after, we computationally docked more
than 301 million virtual molecules against a validated pain target, the α 2A-adrenergic�…
Cite

Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor.

EA Fink, J Xu, H H�bner, JM Braz…�- Science (New York�…, 2022 - europepmc.org
Because nonopioid analgesics are much sought after, we computationally docked more
than 301 million virtual molecules against a validated pain target, the α 2A-adrenergic�…
Cite

Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor.

EA Fink, J Xu, H H�bner, JM Braz…�- Science (New York�…, 2022 - europepmc.org
Because nonopioid analgesics are much sought after, we computationally docked more
than 301 million virtual molecules against a validated pain target, the α 2A-adrenergic�…
Cite